Prezenţa la nivelul structurilor intraoculare normale a acestor factori īn afara oricărei activităţi angiogenetice, sugerează existenţ a unei balanţe fiziologice de menţinere a unei vascularizaţii normale retino-coroidiene, pe tot parcursul vieţii.

Se discută tot mai mult asupra ipotezei că ruperea balanţei fiziologice īntre VEGF ca factor de stimulare a angiogenezei şi PEDF ca factor de inhibiţie a acesteia, să reprezinte elementul declanşator al procesului de neovascularizaţie. Īnţelegerea mecanismelor de acţiune a substanţelor implicate īn inhibarea procesului de neovascularizaţie corioretiniană in vitro şi in vivo, au făcut ca speranţele īn progresul tratamentului acestei patologii să devină reale.

• Angiogeneză,
• Neovascularizaţie oculară,
• VEGF (vascular endothelial growth factor),
• PEDF (pigment epithelium derived factor).

English - Abstract

Over the past several years, there has been important progress in the field of intrinsec mechanisms of ocular neovascularization. Immunohistological studies succeeded a better systematization of the factors that stimulates and inhibits this process. Their presence in different ocular normal structures, without any angiogenic activity, suggests a physiological balance between VEGF (vascular endothelial growth factor) with stimulatory effect on angiogenesis and PEDF (pigment epithelium derived factor) with inhibitory effect.

It has been discussing the possibility of modification of physiological balance between VEGF and PEDF to induce the neovascularization process. The understanding of the physiopathological mechanisms of the substances implicated in inhibition of chorioretinal neovascularization makes to be real the expectations for the development of new treatments.

• Angiogenesis,
• Ocular neovascularization,
• VEGF,
• PEDF.